Status:
COMPLETED
Effects of a Food Preservative on Glucose Homeostasis
Lead Sponsor:
Boston Children's Hospital
Collaborating Sponsors:
Massachusetts General Hospital
Conditions:
Overweight
Eligibility:
All Genders
18-35 years
Phase:
NA
Brief Summary
The investigators propose to examine the effects of the common food preservative sodium benzoate on blood glucose and related hormones and metabolites. If an effect is demonstrated, patients with incr...
Detailed Description
Soft drink consumption has been repeatedly implicated in the development of type 2 diabetes (T2DM). Interestingly, epidemiology studies have yielded inconsistent results. Some studies identify sugar-s...
Eligibility Criteria
Inclusion
- Men and women age 18-35
- BMI 25-30
Exclusion
- Diabetes Mellitus (fasting Blood Glucose ≥ 126mg/dl)
- Exercise more than 60 minutes more that 4 times a week
- Major medical illness
- Medications or supplements that can influence glucose metabolism
- Large fluctuations in weight (\>5% over the past 6 months)
- Currently following a weight loss program
- Consumption of more than 24 ounces of soda per day (defined as sugar- or artificially sweetened beverages, e.g. colas or fruit punches, excluding hot tea and coffee)
- Allergy or intolerance to sodium benzoate
- Nicotine use
- Illicit substance use
- Women with irregular menstrual cycles, or who are pregnant or breastfeeding
Key Trial Info
Start Date :
August 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2011
Estimated Enrollment :
13 Patients enrolled
Trial Details
Trial ID
NCT01179945
Start Date
August 1 2010
End Date
December 1 2011
Last Update
October 1 2012
Active Locations (2)
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1
Massachusetts General Hospital
Boston, Massachusetts, United States, 02101
2
Children's Hospital
Boston, Massachusetts, United States, 02115