Status:
COMPLETED
Intensive Vasodilator Therapy in Patients With Essential Hypertension
Lead Sponsor:
Aarhus University Hospital
Collaborating Sponsors:
University of Aarhus
Conditions:
Essential Hypertension
High Blood Pressure
Eligibility:
All Genders
25-80 years
Phase:
PHASE4
Brief Summary
The purpose of this study is to determine whether add-on of intensive vasodilator therapy can improve the coronary perfusion and reduce the total peripheral resistance in patients with ongoing treatme...
Detailed Description
Morphological changes are observed in the microvasculature of patients with essential hypertension. The lumen diameter is reduced in resistance arteries, but with no change in vessel cross-sectional a...
Eligibility Criteria
Inclusion
- Ongoing antihypertensive treatment for \>3 months
- Blood pressure \>120/75 during antihypertensive treatment
- Ejection fraction \> 45%
Exclusion
- Blood pressure \>160/100
- Pregnancy
- fertile women not using safe contraceptives
- known secondary hypertension
- valvular disease of haemodynamic significance
- known endocrine disease, nephropathy or hepatic disease
- present malignant disease
- known psychiatric disease
- abnormal lab tests of clinical significance
- known allergy to any study medication
- body mass index \> 35
- Ongoing antihypertensive treatment with a combination of ACE-inhibitor and Calcium antagonist.
Key Trial Info
Start Date :
December 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2012
Estimated Enrollment :
48 Patients enrolled
Trial Details
Trial ID
NCT01180413
Start Date
December 1 2010
End Date
April 1 2012
Last Update
April 19 2012
Active Locations (1)
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1
Aarhus University Hospital - dept. cardiology (A)
Aarhus, Denmark, 8000