Status:
COMPLETED
The Importance of Periostin in Periodontal Health and Disease
Lead Sponsor:
University of Michigan
Collaborating Sponsors:
National Institutes of Health (NIH)
National Institute of Dental and Craniofacial Research (NIDCR)
Conditions:
Periodontal Disease
Non-diseased Patients
Eligibility:
All Genders
21+ years
Brief Summary
The goal of this study is to determine the clinical importance of Periostin in oral health and disease. The long-term goal will be to develop practical applications for the diagnosis, treatment, preve...
Detailed Description
It is hypothesized that Periostin levels are decreased during periodontal diseases, thereby, elevating the hosts' susceptibility to periodontal breakdown. The specific aims are the following; To deter...
Eligibility Criteria
Inclusion
- Inclusion criteria for diseased subjects:
- Diagnosis of generalized chronic or aggressive periodontitis
- At least four periodontal sites with probing depth (PD) ≥6 mm, evidence of clinical attachment loss (CAL), and bleeding on probing (BOP). Inclusion criteria for healthy individuals will include PD \<4 mm, no evidence of attachment loss, and \<10% of sites with BOP
- Need an open flap procedure
- Inclusion criteria for non-diseased subjects:
- Subjects requiring a gingivectomy or crown lengthening procedure
Exclusion
- History of alcoholism or drug abuse
- Medical conditions that may affect the outcome such as autoimmune diseases, diabetes, immunocompromised subjects, neurologic or psychiatric disorders, systemic infections, etc.
- Chronic medications known to affect the periodontal status (calcium antagonists, anticonvulsives, immunosuppressives, anti-inflammatory medications, Depo-Provera contraceptive injection users, new oral contraceptives users within 3 months of baseline or subjects that are planning on, starting oral contraceptives during the study.
- Antibiotic therapy within 3 months of the baseline visit, and/or antibiotic therapy needed for infective endocarditis prophylaxis.
- Current use or quit smoking less than one year ago with a pack-year history of more than or equal to 10.
- Untreated cavities
Key Trial Info
Start Date :
June 1 2011
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
February 1 2013
Estimated Enrollment :
22 Patients enrolled
Trial Details
Trial ID
NCT01180920
Start Date
June 1 2011
End Date
February 1 2013
Last Update
December 2 2014
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Michigan Center for Oral Health Research
Ann Arbor, Michigan, United States, 48106