Status:
COMPLETED
Epigenetic Regulation of BDNF in Major Depression
Lead Sponsor:
Chang Gung Memorial Hospital
Conditions:
Major Depressive Disorder
Eligibility:
All Genders
18-60 years
Brief Summary
The investigators will (1) detect the associations between brain-derived neurotrophic factor (BDNF) DNA methylation, histone modification, depressive symptoms, suicidal behavior and antidepressant res...
Detailed Description
Brain-derived neurotrophic factor (BDNF) had been chosen as a candidate gene for a development of major depressive disorder (MDD). BDNF had been reported to have an important role on neuronal plastici...
Eligibility Criteria
Inclusion
- The clinical screening and assessment in patients with major depression：
- 40 major depression will be recruited in psychiatric inpatients according to DSM-IV criteria by a semi-structured interview. The assessment will be done by two senior psychiatrists. The intra-rater and inter-rater reliability will be done before this project started.
- The patients had the ability to complete the written inform consent.
- The choice of antidepressant drugs depended on the need of patients in natural treatment procedure. They included selective serotonin reuptake inhibitors (SSRI), eg. fluoxetine or paroxetine.
- The 17-item Hamilton Depression Rating Scale (HAM-D) was used to assess severity of depression. The minimum baseline score of the 17-item HAM-D was 18.
Exclusion
- The patients had systemic diseases, including metabolic, heart, and liver diseases。
- The patients had received any drugs before entering this protocol.
- The patients were heavy smokers or dependent on alcohol.
- The use of secondary generation anti-psychotic drugs and mood stabilizers.
Key Trial Info
Start Date :
August 1 2010
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
May 1 2013
Estimated Enrollment :
110 Patients enrolled
Trial Details
Trial ID
NCT01182103
Start Date
August 1 2010
End Date
May 1 2013
Last Update
August 15 2014
Active Locations (1)
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1
Department of Psychiatry, Chang Gung Memorial Hospital
Kaohsiung City, Taiwan, 833