Status:
TERMINATED
Dietary Interventions in Asthma Treatment: Sprouts Study
Lead Sponsor:
Johns Hopkins University
Collaborating Sponsors:
National Institutes of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)
Conditions:
Asthma
Allergy
Eligibility:
All Genders
18-49 years
Phase:
NA
Brief Summary
Sulforaphane (SFN) is a naturally occurring isothiocyanate that is a potent inducer of Phase II enzymes which play a critical role in preventing oxidative stress (via activation of Nrf2). Broccoli spr...
Detailed Description
After eligibility is confirmed, participants will be randomized to (a) placebo then BS or (b) BS then placebo. At randomization, baseline exhaled nitric oxide (eNO), forced expiratory volume at one se...
Eligibility Criteria
Inclusion
- Age 18-49 years
- Physician-diagnosed asthma
- No other major pulmonary disease such as cystic fibrosis or chronic obstructive pulmonary disease (COPD)
- Mouse sensitization, defined by a positive skin prick test to mouse epithelial extract or positive mouse-specific immunoglobulin E (IgE)
- Non-smoker
Exclusion
- Severe or unstable asthma defined as requiring hospitalization in the previous year or intubation in the previous 2 years, or on high-dose inhaled corticosteroids or chronic oral corticosteroids
- Baseline FEV1 and FEV1/forced vital capacity (FVC) \< 70% predicted
- Positive skin prick test (SPT) to a pet currently living in the participant's home
- Other significant medical issues such as heart disease or poorly controlled hypertension, or hypothyroidism
- Pregnancy or nursing/breastfeeding mothers
- On beta-blocker therapy
- Taking anti-oxidant supplements
- Unable to stop antihistamines prior to skin testing
- Unable to stop medications that may interfere with allergen challenge responses prior to challenges.
- The participant has food allergy to BS or AS.
- Omalizumab use within the last 12 months.
- Oral corticosteroid use within the last 2 weeks.
Key Trial Info
Start Date :
November 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 6 2012
Estimated Enrollment :
1 Patients enrolled
Trial Details
Trial ID
NCT01183923
Start Date
November 1 2010
End Date
February 6 2012
Last Update
June 4 2019
Active Locations (1)
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1
Johns Hopkins University
Baltimore, Maryland, United States, 21205