Status:
WITHDRAWN
Sulphadoxine-Pyrimethamine for Intermittent Preventive Treatment of Malaria in Pregnancy in Uganda
Lead Sponsor:
University of California, San Francisco
Collaborating Sponsors:
Centers for Disease Control and Prevention
Uganda Malaria Surveillance Project
Conditions:
Intermittent Preventive Treatment
Placental Malaria
Eligibility:
FEMALE
Phase:
PHASE4
Brief Summary
The effectiveness of sulfadoxine-pyrimethamine (SP) as intermittent preventive treatment in pregnancy in malaria-endemic areas the effectiveness and efficacy of SP may be compromised by increased SP r...
Eligibility Criteria
Inclusion
- 16-26 weeks gestation based on LMP or ultrasound or fundal height
- Axillary temperature \<37.5 degrees C
- Informed consent
- HIV status known and negative
- Blood smear positive for falciparum malaria
Exclusion
- History of hypersensitivity reaction to SP or components of SP
- Axillary temperature ≥37.5 degrees C
- History of receipt of antimalarials or antibiotics with antimalarial activity\* in the past month
- Residence \> 30 km from the ANC clinic or unwillingness to return for follow-up visits
- Hemoglobin level \< 5 gm/dL
- These medications include all antimalarials, rifampin, doxycycline, clindamycin, tetracycline, erythromycin, azithromycin, chloramphenicol.
Key Trial Info
Start Date :
October 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2011
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT01184911
Start Date
October 1 2010
End Date
September 1 2011
Last Update
March 5 2015
Active Locations (1)
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1
Infectious Disease Research Center
Tororo, Tororo, Uganda