Status:
COMPLETED
Effect of GLP-1 on Glucose Metabolism in CNS Assessed by PET
Lead Sponsor:
University of Aarhus
Conditions:
Healthy
Eligibility:
MALE
20-50 years
Phase:
PHASE2
PHASE3
Brief Summary
10 healthy men will be PET-scanned (CNS) twice in random order with infusions of placebo or Native GLP-1 during hyperglycemic clamp to uncover the metabolic effects of GLP-1 in perspectives of interve...
Detailed Description
Background Type 2 diabetes (T2D) is epidemically increasing throughout the world. T2D is frequently associated with multiple complications, where particularly the macrovascular complications in the fo...
Eligibility Criteria
Inclusion
- Informed consent signed
- Caucasian
- Male
- Age \> 20 years and \< 50 years
- BMI 20-30 kg/m² -
Exclusion
- Diabetes og first degree relative diabetes
- Clinically significant liver- or kidney-disease (se-ALAT \> 2 times upper reference, or se-Creatinin \> 130 mM
- Anemia
- Other abnormal biochemical value
- Any of the following:
- Heart disease
- Liver disease
- Kidney disease
- Lung disease
- Gastro-intestinal disease
- Dyslipidemia (total serum-cholesterol \> 8 mmol/l, total cholesterol/HDL cholesterol ratio \> 8 or se-triglyceride \> 3.5 mmol/l)
- Endocrine disease (other than diabetes)
- CNS disease
- Hematological disease
- Loss of more than 100 ml blood within the latest month of inclusion
- Compliance problems
- Abuse of alcohol or drugs
- Smoking
- Participation in a clinical research study within 3 months of inclusion
- Allergy towards study hormones
- Medication with any drugs with effects on the glucose-metabolism, including \*glitazones
Key Trial Info
Start Date :
June 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2011
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT01185119
Start Date
June 1 2010
End Date
March 1 2011
Last Update
March 22 2011
Active Locations (1)
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1
Aarhus University, Institute of Pharmacology
Aarhus C, Aarhus, Denmark, 8000