Status:
COMPLETED
Brain Activity and Smoking Cessation
Lead Sponsor:
University of Pennsylvania
Collaborating Sponsors:
National Cancer Institute (NCI)
Conditions:
Nicotine Dependence
Eligibility:
All Genders
18-65 years
Brief Summary
In the current study, the investigators propose to test: (1) whether brain activation and connectivity in a resting state, assessed by ASL perfusion MRI, BOLD fMRI, and diffusion tensor imaging (DTI) ...
Detailed Description
Our previous work demonstrated that, among non-treatment seeking smokers, regional cerebral blood flow (rCBF) is increased following 14 hours of overnight abstinence, as compared to smoking as usual. ...
Eligibility Criteria
Inclusion
- Treatment-seeking smokers between the ages of 18 and 65, reporting consumption of at least 10 cigarettes per day for at least the past 6 months.
- Capable of giving written informed consent, which includes compliance with the requirements and restrictions listed in the combined consent and HIPAA form, and are fluent, English-speaking.
- Provide a baseline CO reading greater than 10 parts per million (ppm) at eligibility screening.
- Women of childbearing potential must consent to use a medically accepted method of birth control (e.g., condoms and spermicide, oral contraceptive, Depo-Provera injection, contraceptive patch, tubal ligation or abstinence from sex) for the duration of the study.
Exclusion
- Smoking Behavior
- Use of chewing tobacco, snuff, or snus.
- Current enrollment or plans to enroll in another research or smoking cessation program in at least the next 7 months.
- Anticipated use (within next 7 months) of other nicotine substitutes or smoking cessation treatments/ medications.
- Provide a baseline CO reading less than or equal to 10ppm.
- Alcohol/Drug
Key Trial Info
Start Date :
April 1 2010
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
February 1 2013
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT01186055
Start Date
April 1 2010
End Date
February 1 2013
Last Update
July 15 2013
Active Locations (1)
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1
3535 Market Street, Suite 4100, University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104