Status:
COMPLETED
Imaging and Biomarkers of Atherosclerosis in Patients With Stable or Unstable Coronary Artery Disease
Lead Sponsor:
Assistance Publique - Hôpitaux de Paris
Collaborating Sponsors:
Institut National de la Santé Et de la Recherche Médicale, France
Conditions:
Atherosclerosis
Coronary Artery Disease
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
In this study, multimodal imaging of atherosclerosis and dosage of new circulating biomarkers will be used to compare patients with stable or unstable coronary artery disease
Detailed Description
Acute complications of coronary and cerebrovascular atherosclerosis -i.e., acute coronary syndromes (ACS) and strokes - remain the principal cause of death worldwide. Identification of patients at hig...
Eligibility Criteria
Inclusion
- First group: Non ST-elevation acute coronary syndrome
- Symptoms compatible with acute myocardial ischaemia
- Presence of either significant ST-T changes without persistent ST elevation or positive troponin I
- And successful stenting of culprit, de novo coronary stenosis located on native coronary arteries
- Second group: Stable coronary artery disease
- Stable angina or silent myocardial ischaemia (documented by a positive stress test)
- And successful stenting of culprit, de novo coronary stenosis located on native coronary arteries
Exclusion
- In both groups
- Absence of percutaneous coronary angioplasty
- IVUS imaging not feasible
- Heart failure (≥NYHA class 2)
- Severe, persistent arrhythmia
- Renal failure (GFR \< 60 ml/min using MDRD formula)
- History of autoimmune or inflammatory disease, recent sepsis (\< 1 month), neoplasm
- Females without contraception (if at childbearing age)
- Pregnant of child feeding females
- Homeless
- Patients with no health coverage
- Refusal to sing informed consent
- Allergy to FDG or iodinated contrast media
- In stable group:
- History of acute coronary syndrome
- History of stroke
Key Trial Info
Start Date :
February 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2013
Estimated Enrollment :
85 Patients enrolled
Trial Details
Trial ID
NCT01186666
Start Date
February 1 2010
End Date
August 1 2013
Last Update
February 25 2015
Active Locations (1)
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1
Département de Cardiologie, Hôpital Bichat, Assistance Publique - Hôpitaux de Paris
Paris, France, 75018