Status:
COMPLETED
The Effect of the Hyperinsulinemic Normoglycemic Clamp on Myocardial Function and Utilization of Glucose
Lead Sponsor:
The Cleveland Clinic
Collaborating Sponsors:
National Institutes of Health (NIH)
Conditions:
Hyperglycemia
Aortic Valve Replacement
Eligibility:
All Genders
40-84 years
Phase:
NA
Brief Summary
The overall research plan is to test the hypothesis that intraoperative treatment of hyperinsulinemic normoglycemic clamp (HNC) in cardiac surgical patients improves myocardial function and short-term...
Detailed Description
Specific Aim #1:To determine whether intraoperative use of HNC affords cardioprotective benefits measured by improved echocardiographic measures of myocardial function, serum markers of cardiomyocyte ...
Eligibility Criteria
Inclusion
- Age 40 - 84 years old, Aortic stenosis, Scheduled for Aortic valve replacement.
Exclusion
- Poor quality echocardiographic images unsuitable for analysis
- Off -pump surgical procedure
- Anticipated deep hypothermic circulatory arrest
- Any contraindications to transesophageal echocardiogram (TEE) or other proposed intervention
- Unable to give written informed consent (non-English speaking, vulnerable patients, etc.)
Key Trial Info
Start Date :
October 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2013
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT01187329
Start Date
October 1 2010
End Date
December 1 2013
Last Update
November 20 2018
Active Locations (1)
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1
Cleveland Clinic Foundation
Cleveland, Ohio, United States, 44195