Status:
COMPLETED
The Effect of Adaptive Servo Ventilation and Oxygen Therapy in Central Sleep Apnea Patients
Lead Sponsor:
Kyoto University, Graduate School of Medicine
Collaborating Sponsors:
Philips Respironics
Philips Healthcare
Conditions:
Chronic Heart Failure
Sleep Apnea
Eligibility:
All Genders
20-80 years
Phase:
NA
Brief Summary
The aim of this study is to compare the effects of Adaptive Servo Ventilation (Bipap® auto SV Advanced) and oxygen therapy in chronic heart failure patients complicated with central sleep apnea.
Detailed Description
Central sleep apnea(CSA) is associated with chronic heart failure(CHF). At present, both of nocturnal oxygen therapy and adaptive servo ventilation(ASV) are recognized as effective modalities. However...
Eligibility Criteria
Inclusion
- Left ventricular ejection fraction\<50% confirmed by echocardiography
- Apnea hypopnea index(AHI)\>=20 confirmed by overnight polysomnography
- More than 15% of AHI is due to CSA
Exclusion
- Changes of cardioactive drug prescriptions within 6 weeks
- Admission due to cardiovascular events within 6 weeks
- Ever used CPAP or ASV for sleep apnea
- Ever used nocturnal oxgen therapy
- Subjects with acute exacerbation of chronic heart failure
- Operation for upper airway within 90 days
- Renal dialysis
- History of stroke with neurological deficit
Key Trial Info
Start Date :
December 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2014
Estimated Enrollment :
43 Patients enrolled
Trial Details
Trial ID
NCT01187823
Start Date
December 1 2010
End Date
March 1 2014
Last Update
April 14 2015
Active Locations (1)
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1
Kyoto University Hospital
Kyoto, Kyoto, Japan, 606-8507