Status:
TERMINATED
Cross-linking of Corneal Collagen (CXL) With Ultraviolet-A in Asymmetric Corneas
Lead Sponsor:
Cxlusa
Conditions:
Keratoconus
Ectasia
Eligibility:
All Genders
12+ years
Brief Summary
The purpose of this study is to evaluate the efficacy of ultraviolet-A (UVA)-induced cross-linking of corneal collagen (CXL) as a method to increase the biomechanical and biochemical stability of the ...
Eligibility Criteria
Inclusion
- 12 years of age or older
- Diagnosis of keratoconus, FFKC, post-LASIK ectasia, or pellucid marginal degeneration or forme fruste pellucid marginal degeneration (FFPMD).
- Diagnosis of FFKC
- History of Radial Keratotomy with fluctuating vision
- Ability to provide written informed consent
- Likely to complete all study visits
- Minimum corneal thickness of at least 300 Measured by ultrasound or Pentacam
- At least 6 months since last corneal surgery (Intacs/PRK/LASIK/Epi-LASIK/LASEK)
Exclusion
- Severe corneal scarring that markedly affects vision
- Contraindications to any study medications or their components
- Pregnancy or breast feeding
- Active Herpes Corneal Disease
Key Trial Info
Start Date :
February 1 2010
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
February 3 2017
Estimated Enrollment :
3493 Patients enrolled
Trial Details
Trial ID
NCT01189864
Start Date
February 1 2010
End Date
February 3 2017
Last Update
October 12 2018
Active Locations (16)
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1
Schwartz Laser Eye Center
Scottsdale, Arizona, United States, 85260
2
Harvard Eye Associates
Laguna Hills, California, United States
3
Clear View Eye & Laser Medical Center
San Diego, California, United States
4
San Francisco, California, United States