Status:
COMPLETED
Chronic Muscle Disuse in the Elderly
Lead Sponsor:
University of Vermont
Collaborating Sponsors:
National Institute on Aging (NIA)
Conditions:
Osteoarthritis
Eligibility:
All Genders
60-80 years
Phase:
NA
Brief Summary
The purpose of this study is to define the effects of chronic disuse on skeletal muscle structure and function in elderly individuals at the cellular and molecular level by examining elderly character...
Detailed Description
Skeletal muscle disuse is an important contributing factor to physical disability. Disuse is more frequent in the elderly and they are more susceptible to its debilitating effects because of their dim...
Eligibility Criteria
Inclusion
- KNEE OSTEOARTHRITIS PATIENTS
- 60-80 yrs of age
- physician-diagnosed, symptomatic knee osteoarthritis
- ambulatory and able to perform lower extremity resistance exercise
Exclusion
- rheumatoid arthritis or other autoimmune disease
- chronic heart, lung, kidney or liver disease or hypertension
- diabetes
- history of stroke
- other neurological or musculoskeletal disease
- HEALTHY CONTROLS
- Criteria are identical to those for knee osteoarthritis patients above, but controls will have no clinical or radiographic evidence of osteoarthritis and will have normal activity physical activity levels.
Key Trial Info
Start Date :
October 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2016
Estimated Enrollment :
35 Patients enrolled
Trial Details
Trial ID
NCT01190046
Start Date
October 1 2010
End Date
June 1 2016
Last Update
November 16 2016
Active Locations (1)
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1
University of Vermont and State Agricultural College
Burlington, Vermont, United States, 05405