Status:
COMPLETED
PET-MR for Prediction and Monitoring of Response to Neoadjuvant Chemotherapy in Breast Cancer
Lead Sponsor:
Seoul National University Hospital
Collaborating Sponsors:
Ministry of Health & Welfare, Korea
Conditions:
Breast Cancer
Eligibility:
FEMALE
18-70 years
Brief Summary
The purpose of this study is: To validate the efficacy of multiparametric MRI, FDG-PET, RGD-PET, and PET-MR fusion imaging in the prediction and monitoring response to neoadjuvant chemotherapy of loc...
Detailed Description
Enrolled women with breast cancers who had received an anthracycline-taxane regimen and subsequent surgery were prospectively enrolled. DCE-MRI and FDG-PET scan were performed before and after the 1st...
Eligibility Criteria
Inclusion
- Pathologically confirmed breast cancer
- Clinical stage IIb, IIIa, IIIb, IIIc
- Must have measurable disease
- Performance status of ECOG 0-2
- Adequate, bone marrow, liver, heart, and renal function
- Who did not receive chemotherapy for breast cancer
- Must agree with and signed informed consent
Exclusion
- Prior history of cancer besides breast cancer
- Active bacterial infection
- Pregnant or lactating women
- Psychological disease or seizure
- History of arrhythmia, congestive heart failure, myocardial infarct, or unstable angina
- Male breast cancer
- Who had a pacemaker or history of open heart surgery
Key Trial Info
Start Date :
May 1 2010
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
May 1 2013
Estimated Enrollment :
57 Patients enrolled
Trial Details
Trial ID
NCT01190566
Start Date
May 1 2010
End Date
May 1 2013
Last Update
July 7 2015
Active Locations (1)
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1
Seoul National University Hospital
Seoul, South Korea, 110-744