Status:
COMPLETED
Effects of Nycthemeral Variations on Computed Tomography (CT) Parameters Reflecting Airways Remodelling, and Pulmonary Emphysema Extent in Chronic Obstructive Pulmonary Disease (COPD)
Lead Sponsor:
Erasme University Hospital
Collaborating Sponsors:
Centre Hospitalier Universitaire Saint Pierre
Conditions:
COPD
CT
Eligibility:
All Genders
40+ years
Brief Summary
Computed tomography (CT) studies considering bronchial dimensions in chronic obstructive pulmonary disease (COPD) have never considered nycthemeral variations. Airway calibre, in COPD patients, exhibi...
Detailed Description
Patients : COPD patients aged 40 years or more, with a smoking history of \> 10 pack-years (PY), a post-bronchodilator forced expiratory volume in one second to vital capacity ratio (FEV1/VC) \< 0.7 a...
Eligibility Criteria
Inclusion
- age 40 or more
- smoking history \> 10 pack-years
- post bronchodilator FEV1/VC \< 0.7
- optimal treatment according to GOLD guidelines
Exclusion
- COPD exacerbation or infection in the 4 weeks before the study
- concomitant pulmonary disease (tuberculosis, significant bronchiectasis, lung cancer)
- pulmonary resection
- active malignancy or malignancy of any organ system within the past 5 years
Key Trial Info
Start Date :
March 1 2010
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
June 1 2011
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT01192932
Start Date
March 1 2010
End Date
June 1 2011
Last Update
July 4 2012
Active Locations (1)
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1
C.H.U Saint-Pierre
Brussels, Belgium, 1000