Status:
COMPLETED
A Trial to Evaluate the Impact of Lung-protective Intervention in Patients Undergoing Esophageal Cancer Surgery
Lead Sponsor:
Shanghai Zhongshan Hospital
Conditions:
Acute Lung Injury
Eligibility:
All Genders
18-80 years
Phase:
NA
Brief Summary
The purpose of this trial is to determine whether low tidal volume during intraoperative one-lung ventilation could decrease the incidence rate of postoperative acute lung injury compared to "normal" ...
Detailed Description
Large tidal volume are known risk factor of acute lung injury.Mechanical ventilation with low tidal volume has been shown to attenuate lung injuries in critically ill patients.Esophagectomy surgery ne...
Eligibility Criteria
Inclusion
- clinical diagnosis of esophageal carcinoma and planned for esophagectomy
- indication for one-lung ventilation
- informed consent
- ASA I\~II
Exclusion
- NYHA III\~IV
- severe COPD
- pulmonary fibrosis
- any new pulmonary infiltrate on chest radiograph
- preoperative acute infection suspected
- altered liver function( Child-Pugh class B or moe)
- acute or chronic renal failure
- preoperative corticosteroid treatment during month before inclusion
Key Trial Info
Start Date :
August 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2013
Estimated Enrollment :
101 Patients enrolled
Trial Details
Trial ID
NCT01194895
Start Date
August 1 2010
End Date
March 1 2013
Last Update
March 14 2013
Active Locations (1)
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1
180 Fenglin Road
Shanghai, China, 20032