Status:
COMPLETED
The Effects of Amiloride and Spironolactone on Renophysiological and Cardiovascular Variables
Lead Sponsor:
Regional Hospital Holstebro
Conditions:
Essential Hypertension
Eligibility:
All Genders
40-70 years
Phase:
NA
Brief Summary
The investigators wish to study the effect of retaining potassium. The participants have essential hypertension. The test substances are Amiloride, Spironolactone and placebo. The participants will in...
Detailed Description
Purpose of the study is to examine the effect of amiloride and spironolactone on 1. Renal function (GFR, u-AQP2, u-ENaCβ, u-cAMP, u-PGE2, CH20, FENa, FEK), 2. Pulsewave velocity, augmentation index c...
Eligibility Criteria
Inclusion
- hypertension,
- BMI 18,5-30,
- non-smoker
Exclusion
- Smoking
- Not using contraceptives
- Other illnesses
- Drug or alcohol abuse
Key Trial Info
Start Date :
August 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 1 2015
Estimated Enrollment :
25 Patients enrolled
Trial Details
Trial ID
NCT01195805
Start Date
August 1 2010
End Date
August 1 2015
Last Update
August 20 2015
Active Locations (1)
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1
Departments of medical research and medicine
Holstebro, Denmark, 7500