Status:
UNKNOWN
Anterior and Posterior Segment Vascular Changes Following Laser and Anti-Vascular Endothelial Growth Factor (VEGF) Treatment of Diabetic Retinopathy
Lead Sponsor:
University of Toronto
Collaborating Sponsors:
Ontario Research Fund
Conditions:
Diabetic Macular Edema
Eligibility:
All Genders
35-75 years
Brief Summary
The study will investigate changes in the structure and function of blood vessels in the front and back of the eye following laser and anti-VEGF treatments for sight-threatening diabetic eye disease. ...
Detailed Description
Diabetic Retinopathy (DR) is the single leading cause of blindness in people of working age. The total number of people living with diabetes in Canada is well over 2 million. The WHO estimates that ar...
Eligibility Criteria
Inclusion
- Age range of 35-75 yrs
- Type 2 diabetes apart from age-matched control group
- Visual acuity of 20/400 or better
- Confirmed diagnose of Clinical Significant Diabetic Macular Edema (applies for Diabetic Groups only)
- Previously untreated eye for retinal diseases and disorders
Exclusion
- Distance refractive error \> ± 6.00 DS \& / or ± 2.50 DC
- Intraocular pressure ≥ 22mm Hg
- Proliferative Diabetic Retinopathy
- Any other active eye disease and disorder
- Participants with history of cardiovascular events, stroke, thromboembolic events, transient ischemic attack, uncontrolled hypertension.
- Any active ocular infection;
- History of glaucoma;
- Known allergy, hypersensitivity or contraindication to the study medication;
- Pregnancy, breast feeding, or women of childbearing potential who are not using a reliable method of contraception;
- Proteinuria and/or renal impairment;
- Surgery within the past 28 days.
Key Trial Info
Start Date :
July 1 2009
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
August 1 2014
Estimated Enrollment :
64 Patients enrolled
Trial Details
Trial ID
NCT01196325
Start Date
July 1 2009
End Date
August 1 2014
Last Update
January 24 2013
Active Locations (1)
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1
Toronto Western Hospital
Toronto, Ontario, Canada, M5T2S8