Status:
COMPLETED
PET Brain and Whole Body Distribution Studies for Nociceptin/Orphanin FQ Peptide (NOP) Receptor Using [11C]NOP-1A
Lead Sponsor:
National Institute of Mental Health (NIMH)
Conditions:
Pain
Anxiety
Eligibility:
All Genders
18-50 years
Phase:
EARLY_PHASE1
Brief Summary
Background: \- A small brain protein called nociceptin/orphanin FQ peptide (NOP) receptor may be involved in several brain diseases such as anxiety, depression, drug abuse, and seizures. Researchers ...
Detailed Description
Nociceptin/orphanin FQ peptide (NOP) receptor is a new class of opioid receptor cloned in 1994 before identifying the endogenous ligand. Within a year, endogenous ligand was identified and soon many l...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Healthy Volunteers:
- Subjects must be adults between 18-50 years old.
- Subjects must be able and willing to give written informed consent.
- EXCLUSION CRITERIA:
- Current psychiatric illness or severe systemic disease based on history and physical exam.
- If women, pregnancy or breast feeding (betaHCG will be measured in all female patients within 24 hours of scan and must be negative)
- Clinically significant laboratory abnormalities.
- Serious medical problems including but not limited to chronic neurological disease such as multiple sclerosis, autoimmune diseases or any cardiopulmonary disease.
- Head trauma resulting in a period of unconsciousness lasting longer than 10 minutes.
- Recent exposure to radiation (i.e., PET from other research) which when combined with this study would be above the allowable limits.
- Positive urine drug screen at screening.
- Inability to lie flat on camera bed for about 2.5 hours
- Subjects who have metallic foreign bodies that would be affected by the MRI magnet, or fear of enclosed spaces likely to make the subject unable to undergo an MRI scan.
Exclusion
Key Trial Info
Start Date :
September 3 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 28 2014
Estimated Enrollment :
41 Patients enrolled
Trial Details
Trial ID
NCT01198197
Start Date
September 3 2010
End Date
February 28 2014
Last Update
December 17 2019
Active Locations (1)
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1
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892