Status:
COMPLETED
Preoperative Misoprostol in Reducing Blood Loss in Total Abdominal Hysterectomy (TAH)
Lead Sponsor:
The University of Hong Kong
Conditions:
Hysterectomy
Eligibility:
FEMALE
Phase:
NA
Brief Summary
Total abdominal hysterectomy is known to be associated with operative blood loss, which can lead to patients' morbidity. Misoprostol, a prostaglandin, has been shown to be effective in reducing operat...
Detailed Description
Uterine leiomyoma is the commonest benign tumour affecting women in their reproductive age. Around 20-50% can cause symptoms that warrant treatment. Different medical therapies, including gonadotrophi...
Eligibility Criteria
Inclusion
- symptomatic women undergoing total abdominal hysterectomy for various benign gynaecological diseases in Queen Mary Hospital
Exclusion
- any contraindication to misoprostol, including mitral stenosis, glaucoma, sickle cell anaemia, diastolic pressure over 100mmHg, severe asthma, or known allergy to prostaglandin;
- a known history of pelvic/ovarian endometriosis;
- a known history of or active medical disease;
- a known history of previous myomectomy;
- women who had pre-operative mifepristone or gonadotrophin releasing hormone analogues treatment;
- women with mental impairment or incompetent in giving consent.
Key Trial Info
Start Date :
January 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2008
Estimated Enrollment :
77 Patients enrolled
Trial Details
Trial ID
NCT01199159
Start Date
January 1 2007
End Date
April 1 2008
Last Update
September 10 2010
Active Locations (1)
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1
University of Hong Kong
Hong Kong, Hong Kong