Status:
TERMINATED
Impact of Physical Activity on Left Ventricular Mass and Lipid Metabolism
Lead Sponsor:
University of California, San Francisco
Conditions:
Left Ventricular Hypertrophy
Eligibility:
All Genders
18+ years
Brief Summary
Prospective study on the structural and functional changes in the heart of adult women assessed by echocardiogram and in lipid metabolism that occur in response to physical training. Using echocardiog...
Detailed Description
Left ventricular hypertrophy, defined as an increase in the mass of the left ventricle may occur as a physiologic response to exercise (athletic remodeling aka "athletic heart"), but is most frequentl...
Eligibility Criteria
Inclusion
- Healthy adult men or women, aged 18 years or older
- Voluntarily signed up for a sport event or to run a marathon or a half marathon for the first time
- Normal to mildly elevated blood pressure (systolic blood pressure \< 140 mmHg and/or diastolic blood pressure \< 90 mmHg)
- Hormone replacement therapy and birth control pills are allowed, provided they have been on a stable dose for more than 3 months and no change in dose is planned for the duration of the study
- Capable and willing to provide written, informed consent for the study
Exclusion
- History of cardiovascular disease within the past year (cardiomyopathy, heart failure, ischemic heart disease, stroke, TIA, peripheral vascular disease)
- Change in body weight more than 10% over the past year
- History of significant medical conditions, including respiratory, gastrointestinal, neuromuscular, neurological or musculoskeletal problems interfering with exercise.
- Autoimmune or collagen vascular diseases, chronic anemia,
- Malignancies in the past 5 years, with the exception of treated skin or breast cancer that did not require treatment with chemotherapy.
- Diabetes
- Pregnancy or recent delivery: delivery date less than 3 months prior to enrollment
- Lipid lowering medications (statins, niacin, resins) are allowed, provided dose has not changed for 3 months prior to enrollment and is not anticipated to change during the study
- Fish Oil supplements are allowed, provided dose has been unchanged for 3 months prior to enrollment and no change in dose is planned for the duration of the study.
Key Trial Info
Start Date :
February 1 2011
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
October 1 2017
Estimated Enrollment :
187 Patients enrolled
Trial Details
Trial ID
NCT01199211
Start Date
February 1 2011
End Date
October 1 2017
Last Update
July 31 2020
Active Locations (1)
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1
CTSI - University of California San Francisco
San Francisco, California, United States, 94143