Status:
COMPLETED
Impact of Anesthetic Choice (Sevoflurane Versus Desflurane) on Airway Reflex Recovery in the Context of Antagonized Neuromuscular Block
Lead Sponsor:
University of California, San Francisco
Collaborating Sponsors:
Baxter Healthcare Corporation
Conditions:
Airway Reflexes, Protective
Recovery After Neuromuscular Block
Eligibility:
All Genders
18-65 years
Phase:
PHASE4
Brief Summary
Protective airway reflexes may be impaired in the postoperative period, creating the potential for aspiration of gastric contents, even after a patient exhibits appropriate response to command. Becaus...
Eligibility Criteria
Inclusion
- ASA 1-2 patients
- Age 18-65 years
- body mass index (BMI) ≤ 35kg/m2
- Planned surgery requiring general anesthesia lasting approximately 1.5-3.0 hours
- Surgery requires or benefits from skeletal muscle relaxation
- All must pass the baseline 20 mL water swallowing test as previously described.
Exclusion
- Pre-existing neuromuscular or central nervous system disorder
- Known condition interfering with gastric emptying
- Planned surgical procedure on the head or neck
- Known liver disease
- Serum creatinine \> 1.5 mg/dL
- Concurrent use of neuroleptic medications
- Contraindication or previous adverse response to any of the study drugs
- Active asthma or reactive airways disease
- Surgery where upright position or brief cough would be contraindicated
- Inability to provide informed consent
Key Trial Info
Start Date :
August 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2013
Estimated Enrollment :
107 Patients enrolled
Trial Details
Trial ID
NCT01199237
Start Date
August 1 2010
End Date
August 1 2013
Last Update
May 16 2014
Active Locations (2)
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1
UCSF Helen Diller Cancer Center
San Francisco, California, United States, 94115
2
UCSF Moffitt-Long Hospital
San Francisco, California, United States, 94143