Status:
COMPLETED
Effect of a Component of Fish Oil on Exercise-Induced Bronchoconstriction and Airway Inflammation in Asthma
Lead Sponsor:
Indiana University
Conditions:
Asthma
Eligibility:
All Genders
18-40 years
Phase:
NA
Brief Summary
Docosahexaenoic acid (DHA) is a component of fish oil that is known to support a healthy cardiovascular system, maintain brain function, reduce depression, and improve inflammatory diseases. The study...
Detailed Description
To date, fish oil supplementation studies in patients with asthma have used a combination of omega-3 polyunsaturated fatty acids. A study on the specific formula that is most effective in preventing e...
Eligibility Criteria
Inclusion
- Diagnosis of asthma, based on medication use as well as history and symptoms as outlined in the NHLBI Guidelines for the Diagnosis and Management of Asthma
- Diagnosis of EIB, based on a ≥10% fall in FEV1, a measure of lung function, after dry air eucapnic voluntary hyperventilation (EVH), a simulated exercise challenge
- Not currently taking asthma maintenance medication or physician approval to discontinue current asthma medication for the duration of the study
- Not currently taking any fish oil supplements above the level recommended for adequate intake (if currently taking supplements, can participate if the subject stops taking the supplements for 2 weeks before starting the study and throughout the study)
- Agree to limit fish consumption to 1 fish meal per week throughout the study
Exclusion
- Post-EVH FEV1 (the amount of air blown out in the first second of a forced exhalation) decreases by more than 50% compared to the subject's resting FEV1 at the first lab testing session
- Pregnancy
- History of cardiovascular disease, including hyperlipidemia (high cholesterol) and hypertension (high blood pressure)
- History of bleeding disorders or delayed clotting time
- History of diabetes
- History of seizures
- Allergy to fish oil
- Allergy to corn or soy products (placebo is a mixture of corn and soy oil)
Key Trial Info
Start Date :
October 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
January 1 2011
Estimated Enrollment :
16 Patients enrolled
Trial Details
Trial ID
NCT01200446
Start Date
October 1 2010
End Date
January 1 2011
Last Update
May 26 2011
Active Locations (1)
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1
Indiana University
Bloomington, Indiana, United States, 47405