Status:
TERMINATED
Collection of Blood, Bone Marrow, Leukapheresis, and Tissue Biopsy Samples From Patients and Their Family Members for Center for Human Immunology, Autoimmunity, and Inflammatory Diseases Laboratory Research Studies
Lead Sponsor:
National Institute of Allergy and Infectious Diseases (NIAID)
Conditions:
Idopathic Inflammatory/Autoimmune Syndromes
Eligibility:
All Genders
2+ years
Brief Summary
Background: \- The Center for Human Immunology, Autoimmunity, and Inflammatory Diseases (CHI) is conducting a variety of laboratory research experiments that require blood, bone marrow, urine, stool,...
Detailed Description
BACKGROUND Clinical investigators in the Center for Human Immunology, Autoimmunity, and Inflammatory Diseases (CHI) study the pathophysiology of a wide variety of immune-mediated and inflammatory dis...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA
- Affected Adults
- The subject carries the diagnosis of an immune-mediated or inflammatory disease, or has signs or symptoms of an immune or inflammatory disease without a formal diagnosis.
- Age 18 years and older (no upper limit)
- Affected Children
- The subject carries the diagnosis of an immune-mediated or inflammatory disease, or has signs or symptoms of an immune or inflammatory disease without a formal diagnosis.
- Age 2 years and older (no upper limit)
- Unaffected Child Relatives
- Immediate family members (child, sibling, grandchild) of individuals included under item (Affected Adult)
- Subjects over 2 years of age may (but \< 18 years of age) be seen for initial evaluations, genetic studies, or research blood specimens, or may send blood or buccal samples for genetic testing only. Unaffected family members will not be asked to undergo leukapheresis, bone marrow aspirations and biopsies, or other invasive procedures.
- Unaffected Adult Relatives
- Immediate family members (parent, child, sibling, grandchild) of individuals included under item (Affected Adult)
- Subjects over 18 years of age may be seen for initial evaluations, genetic studies, or research blood specimens, or may send blood or buccal samples for genetic testing only. Unaffected family members will not be asked to undergo leukapheresis, bone marrow aspirations and biopsies, or other invasive procedures.
- EXCLUSION CRITERIA: (All groups)
- Subjects or their parents or guardians who are unable to comprehend the investigational nature of the procedure. The subject or the subject s guardian is unable to understand the investigational nature of the study and provide informed consent after initial counseling by clinical staff. Only adults capable of signing consent will be eligible. Separate consent forms for all interventional or surgical procedures will be obtained after explanation of the specific procedure.
- Pregnant unaffected relatives will be excluded.
- Subjects not willing to participate in the genetic analysis and whole genomic analysis portion of this study.
Exclusion
Key Trial Info
Start Date :
July 1 2010
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
September 18 2018
Estimated Enrollment :
96 Patients enrolled
Trial Details
Trial ID
NCT01200823
Start Date
July 1 2010
End Date
September 18 2018
Last Update
September 20 2018
Active Locations (1)
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1
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892