Status:
COMPLETED
Tripartite International Research for the Elimination of Trachoma
Lead Sponsor:
University of California, San Francisco
Conditions:
Trachoma
Chlamydia
Eligibility:
All Genders
1+ years
Phase:
PHASE4
Brief Summary
Mass antimicrobial administrations have been remarkably successful in reducing the prevalence of the ocular strains of Chlamydia that cause trachoma. Repeated distributions progressively lower the pre...
Detailed Description
The proposed study is a group-randomized trial to determine the frequency and treatment target of community-wide mass antibiotic treatment to eliminate trachoma. We will continue to monitor a sub-set ...
Eligibility Criteria
Inclusion
- All residents residing in the state-teams which are randomly selected for this study.
Exclusion
- Pregnant women
- Children under 6 months of age
- All those who are allergic to macrolides or azalides
- Refusal of village chief (for village inclusion), or refusal of parent or guardian (for individual inclusion)
- Individuals in these three exclusion criteria will not be given the study antibiotic azithromycin, but offered the current WHO-recommended alternative treatment to azithromycin for active trachoma, which is 1% tetracycline eye ointment, to be used twice a day, topically to both eyes, for six weeks. Note that the exclusion criteria refer to the exclusion to the treatment drug, but not to the monitoring, treatment of trachoma, and examinations.
Key Trial Info
Start Date :
November 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2014
Estimated Enrollment :
29000 Patients enrolled
Trial Details
Trial ID
NCT01202331
Start Date
November 1 2010
End Date
May 1 2014
Last Update
October 11 2017
Active Locations (1)
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1
The Carter Center, Ethiopia
Addis Ababa, Ethiopia