Status:
COMPLETED
Pharmacogenomic Evaluation of Antihypertensive Responses 2
Lead Sponsor:
University of Florida
Collaborating Sponsors:
National Institute of General Medical Sciences (NIGMS)
Conditions:
Hypertension
Eligibility:
All Genders
18-65 years
Phase:
PHASE4
Brief Summary
There are many medications available for the treatment of high blood pressure (hypertension), but finding the right one for a specific patient can be challenging. In fact, it is estimated that less th...
Detailed Description
The proposed work should help move toward the long-term goal of selection of antihypertensive drug therapy based on a patient's genetic make-up. Hypertension (HTN) is the most common chronic disease f...
Eligibility Criteria
Inclusion
- An average seated home diastolic blood pressure (DBP) \> 85 mmHg and \< 110 mmHg and home systolic blood pressure (SBP) \< 180 mmHg.
- Subjects must also have an average seated (\> 5 minutes) clinic DBP between 90 mmHg and 110 mmHg and SBP \< 180 mmHg
Exclusion
- Secondary forms of hypertension (HTN) (including sleep apnea)
- Isolated systolic HTN
- Other diseases requiring treatment with BP lowering medications
- Heart rate \< 55 beats/min (for metoprolol only)
- Known cardiovascular disease (including history of angina pectoris, heart failure, presence of a cardiac pacemaker, history of myocardial infarction or revascularization procedure, or cerebrovascular disease, including stroke and TIA)
- Diabetes mellitus (Type 1 or 2)
- Renal insufficiency (serum creatinine \> 1.5 in men or 1.4 in women)
- Primary renal disease
- Pregnancy or lactation
- Liver enzymes \> 2.5 upper limits of normal
- Current treatment with NSAIDS, cyclooxygenase-2 (COX2) inhibitors, oral contraceptives or estrogen.
Key Trial Info
Start Date :
August 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2014
Estimated Enrollment :
839 Patients enrolled
Trial Details
Trial ID
NCT01203852
Start Date
August 1 2010
End Date
April 1 2014
Last Update
April 6 2018
Active Locations (3)
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1
University of Florida
Gainesville, Florida, United States, 32610
2
Emory University School of Medicine
Atlanta, Georgia, United States, 30322
3
Mayo Clinic, Division of Hypertension
Rochester, Minnesota, United States, 55905