Status:
COMPLETED
Proportional Assist Ventilation (PAV) in Early Stage of Critically Ill Patients
Lead Sponsor:
Althaia Xarxa Assistencial Universitària de Manresa
Collaborating Sponsors:
Medtronic - MITG
Conditions:
Respiratory Failure
Mechanical Ventilation
Eligibility:
All Genders
18-90 years
Phase:
PHASE4
Brief Summary
To evaluate the effectiveness of high assistance proportional assist ventilation (PAV+) (objective 80% gain) as main ventilatory support in early stage of critically ill patients in comparison with st...
Detailed Description
The goal of this proposal is to apply PAV+ as routine ventilatory mode in the early stage of critically ill patients, taking advantages of spontaneous breathing and better patient-ventilator interacti...
Eligibility Criteria
Inclusion
- Patients 18 years of age or older
- Anticipated MV \> 24 hours
- Availability of informed consent from patient or next of kin
- Ventilation parameters measured under PAV+ 80% gain:
- PaO2/FiO2 \>100 RPAV \<10 cm H2O/l/s CPAV \> 30 ml/cm H2O WOBTOT \<1.5 J/l VE \<18 l/min
Exclusion
- Patients on moribund state or with life-sustaining therapy withholding decision.
- Patients with unstable respiratory/hemodynamic state, PaO2/FiO2 \<100, Dopamine \>15 microg/Kg/min or epinephrine \>0.1 microg/kg/min.
- Pregnancy.
- Air leak.
- Patients needing deep sedation or muscle paralysis
- Patients needing hyperventilation (brain trauma).
- Patients with severe muscle weakness.
- Recruitment maneuvers or prone position.
Key Trial Info
Start Date :
September 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2012
Estimated Enrollment :
110 Patients enrolled
Trial Details
Trial ID
NCT01204281
Start Date
September 1 2010
End Date
September 1 2012
Last Update
November 27 2012
Active Locations (1)
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1
Intensive Care Unit. Xarxa assistencial Althaia.
Manresa, Catalonia, Spain, 08243