Status:
TERMINATED
Suicide Gene Therapy Trial
Lead Sponsor:
Great Ormond Street Hospital for Children NHS Foundation Trust
Conditions:
Haploidentical Stem Cell Transplantation
Eligibility:
All Genders
Up to 16 years
Phase:
PHASE1
PHASE2
Brief Summary
Bone marrow or blood stem cell transplantation is used to treat a wide range of life-threatening conditions. T lymphocytes carried in the graft have powerful beneficial effects and play a vital role i...
Eligibility Criteria
Inclusion
- Patients with primary immunodeficiencies, haematological malignancies or metabolic disorders at GOSH (children of both sexes, aged 0 to 16 years) undergoing haploidentical transplant
- Both patient and donor must give informed consent in writing.
- The donor must be willing, able and available for donation of T cells by collection of whole blood or leukapheresis.
- The patient should be free of serious intercurrent illness.
Exclusion
- Donor unfit or unavailable
- Donor positive for Hepatitis B or C, or HTLV-1, or HIV
- Patient receiving Ganciclovir, Aciclovir, Cidofovir a result of active CMV, adenovirus, varicella zoster or herpes simplex infection infection
- GVHD ≥ grade II before infusion of gene modified T cells
- Serious intercurrent illness
Key Trial Info
Start Date :
January 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2013
Estimated Enrollment :
2 Patients enrolled
Trial Details
Trial ID
NCT01204502
Start Date
January 1 2011
End Date
January 1 2013
Last Update
September 18 2013
Active Locations (1)
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1
Great Ormond Street Hospital for Children NHS Trust
London, United Kingdom, WC1N 3JH