Status:
COMPLETED
Effects of Doxycycline on Persistent Symptoms Post-neuroborreliosis
Lead Sponsor:
Linkoeping University
Conditions:
Fatigue
Radicular Pain
Eligibility:
All Genders
18-85 years
Phase:
NA
Brief Summary
The aim of this randomised, double-blind crossover study was to determine whether Doxycycline has an impact on the persistent symptoms post-neuroborreliosis, through alterations in the immune response...
Detailed Description
Persistent symptoms after treatment of neuroborreliosis (NB) are not uncommon. There is currently no evidence for improvement of symptoms after repeated or prolonged antibiotic treatment. However, cli...
Eligibility Criteria
Inclusion
- a history of adequately diagnosed and treated neuroborreliosis (presence of intrathecal borrelia-antibody production)
- persistence of symptoms (with debut in conjunction with neuroborreliosis) of typical character, such as headache, radiculitis, cognitive dysfunction, fatigue, mood disorders, paresthesia or paresis \> 6 months post-treatment of neuroborreliosis
Exclusion
- systemic immunosuppression (treatment with corticosteroids, cytostatics etc)
- ongoing infection at inclusion
- allergy against doxycycline
- pregnancy
- breast feeding
- psychiatric disease
- multiple sclerosis
- rheumatoid arthritis
- diabetes mellitus type 1 or II
- inflammatory systemic diseases
- liver ohc kidney dysfunction
- treatment with didanosine, quinapril, antacids
- malignancy
Key Trial Info
Start Date :
February 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 1 2008
Estimated Enrollment :
15 Patients enrolled
Trial Details
Trial ID
NCT01205464
Start Date
February 1 2005
End Date
February 1 2008
Last Update
September 20 2010
Active Locations (1)
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1
Clinic for Infectious Diseases, University Hospital
Linköping, Östergötland County, Sweden, 58185