Status:
COMPLETED
Applications of Nanotechnology in Multiple Sclerosis by Respiratory Samples
Lead Sponsor:
Carmel Medical Center
Collaborating Sponsors:
Technion, Israel Institute of Technology
Conditions:
Multiple Sclerosis
Eligibility:
All Genders
18-60 years
Brief Summary
Multiple Sclerosis (MS) is a complex multi-factorial disease, with underlying both genetic and environmental factors. Different populations have different susceptibility. The disease is characterized ...
Detailed Description
Multiple Sclerosis (MS) is a complex multi-factorial disease, with underlying both genetic and environmental factors. Different populations have different susceptibility. The disease is characterized ...
Eligibility Criteria
Inclusion
- MS patients:
- Relapsing remitting (RRMS) meeting the clinical criteria of McDonald (Polman, Reingold et al. 2005) that presented in the MS clinic in Carmel hospital, Haifa Israel. Relapsing MS patients that never received, or have received in the past, or, are currently receiving, or, are about to commence immunomodulator treatment.
- MS patients presenting in acute relapse and about to commence a treatment regimen of corticosteroids (IV-Methylprednisolone and oral prednisone)
- Primary progressive (PPMS) meeting the clinical criteria of McDonald (Polman, Reingold et al. 2005)that presented in the MS clinic in Carmel hospital, Haifa Israel. Tissue will be collected as previously described.
- Willing and able to give inform consent
- Control subjects:
- Age and gender match control individuals that do not have MS or any other condition that is defined as "autoimmune". These individuals will be recruited as "Healthy Population Reference" group.
- Willing and able to give informed consent
Exclusion
- Patients age 18 or less, pregnant women
- Presence of HIV, hepatitis or any other potentially severe and infectious disease. Healthy individual with up to third degree relatives with MS or any other autoimmune diseases.
- Exclusion from the experiment during the study period:
- Any new clinical information that is not consistent with inclusion criteria.
- Technical problems in the performance of the tests.
Key Trial Info
Start Date :
November 1 2010
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
November 1 2012
Estimated Enrollment :
71 Patients enrolled
Trial Details
Trial ID
NCT01206023
Start Date
November 1 2010
End Date
November 1 2012
Last Update
February 23 2017
Active Locations (2)
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1
MS Clinic, Carmel Medical Center
Haifa, Israel, 34362
2
MS Clinic, Carmel Medical Center
Haifa, Israel