Status:
UNKNOWN
Evaluation of Customized Treatment According to BRCA1 Assessment in Patients With Advanced Gastric Cancer
Lead Sponsor:
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Conditions:
Advanced Gastric Cancer
Eligibility:
All Genders
18+ years
Phase:
PHASE2
PHASE3
Brief Summary
Evaluation of customized treatment according to BRCA1 assessment in patients with advanced gastric cancer
Eligibility Criteria
Inclusion
- Provision of informed consent
- Female or male aged 18 years and over
- Histologic or cytologic confirmation of advanced gastric cancer
- Stage III-IV (AJCC 7th)
- ECOG: 0-2
- Have tumor sample that can be tested for BRCA1 mRNA expression
- Negative pregnancy test for women of childbearing potential
- Neutrophile granulocyte greater than 1.5×10\^9/L
- Hemoglobin greater than 10g/dL
- Platelet greater than 100×10\^9/L
- Serum bilirubin not greater than 1.5x upper limit of reference range (ULRR)
- ALT or AST not greater than 1.5x ULRR
- Creatinine clearance no less than 60ml/min
Exclusion
- Have at least another primary malignant tumor
- Active infection
- Chemotherapy with experimental drug within 3 weeks before the start of study therapy
- Women who are pregnant or breast feeding
- Weight loss greater 10% within 6 weeks before the start of study therapy
Key Trial Info
Start Date :
October 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
Estimated Enrollment :
96 Patients enrolled
Trial Details
Trial ID
NCT01206218
Start Date
October 1 2010
Last Update
September 21 2010
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