Status:
COMPLETED
The Swedish BioFINDER Study
Lead Sponsor:
Skane University Hospital
Collaborating Sponsors:
Lund University
Conditions:
Mild Cognitive Impairment
Alzheimer's Disease
Eligibility:
All Genders
60-80 years
Brief Summary
The present study aims at combining biochemical methods with various types of imaging techniques to identify the pathophysiology of Alzheimer's disease (AD). The main interest is to find markers assoc...
Detailed Description
1. Baseline investigations of patients with mild cognitive deficits We are conducting a prospective, longitudinal study in which we consecutively include patients with mild cognitive deficits (MCI...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- Healthy elderly subjects
- No cognitive symptoms reported by patient and/or informant
- Normal performance on cognitive tests
- General cognition and functional performance preserved such that a diagnosis of MCI or dementia cannot be made by physician at the time of the baseline visit
- Between 60 and 90 years of age
- Fluent in Swedish
- Agrees to at least one lumbar puncture, and neuropsychological testing.
- Mild cognitive impairment
- Cognitive symptoms reported by patient and/or informant
- Between 60 and 80 years of age
- Mini-Mental State Exam score between 24 and 30
- General cognition and functional performance sufficiently preserved such that a diagnosis of dementia cannot be made by physician at the time of the baseline visit
- Fluent in Swedish
- Agrees to at least one lumbar puncture, and neuropsychological testing.
- Exclusion Criteria (for both MCI and healthy elderly):
- Any significant neurologic disease other than dementia disorders, such as Huntington's disease, normal pressure hydrocephalus, brain tumor, seizure disorder, subdural hematoma, multiple sclerosis, or history of significant head trauma followed by persistent neurologic defaults or known structural brain abnormalities.
- Major depression as described in DSM-IV.
- History of schizophrenia or other recurrent psychotic disorder
- History of alcohol or substance abuse or dependence within the past 5 years
Exclusion
Key Trial Info
Start Date :
September 1 2010
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 1 2024
Estimated Enrollment :
1150 Patients enrolled
Trial Details
Trial ID
NCT01208675
Start Date
September 1 2010
End Date
December 1 2024
Last Update
April 27 2025
Active Locations (2)
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1
Memory Clinic, Hospital of Ängelholm
Ängelholm, Sweden
2
Memory Clinic, Skåne University Hospital
Malmo, Sweden, 20502