Status:
COMPLETED
Local Vasoconstriction in Postural Tachycardia Syndrome
Lead Sponsor:
New York Medical College
Conditions:
Postural Tachycardia Syndrome
Eligibility:
All Genders
14-29 years
Phase:
EARLY_PHASE1
Brief Summary
The investigators study will determine how often blood flow regulation abnormalities and abnormalities of sympathetic regulation produced by nitric oxide, angiotensin-II, and oxidative stress occur in...
Detailed Description
Chronic orthostatic intolerance due to the postural tachycardia syndrome (POTS) severely impairs daily life in over a million Americans, mostly young women. POTS is defined by symptoms of orthostatic ...
Eligibility Criteria
Inclusion
- Cases will be between the ages of 14 and 29 years old referred for evaluation of orthostatic intolerance with 3 or more of the following symptoms for at least 3 months:
- dizziness
- nausea and vomiting
- palpitations
- fatigue
- headache
- exercise intolerance
- blurred vision
- abnormal sweating heat.
- Cases will have the diagnosis of symptomatic postural tachycardia made during a screening tilt table test.
- Cases will have normal physical examination, and normal electrocardiographic and echocardiographic evaluations.
- Only those free from heart disease, and from systemic illness will be eligible to participate.
- This excludes patients with illnesses and disease states known to be associated with endothelial cell dysfunction such as diabetes, renal disease, congestive heart failure, systemic hypertension, acute and chronic inflammatory diseases, neoplasm, immune mediated disease, trauma, morbid obesity and peripheral vascular disease.
- At the time of testing all patients and control subjects must refrain from vasoactive drugs for two weeks. Please check with us about any medication that you are taking.
Exclusion
- Criteria for initial exclusion will include a condition known to be associated with endothelial dysfunction
- An active medical condition that may explain the diagnosis
- A previous medical condition with undocumented resolution that may explain the diagnosis
- Past or present major psychiatric disorder
- Substance abuse within 2 years before onset of symptoms.
Key Trial Info
Start Date :
July 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2015
Estimated Enrollment :
74 Patients enrolled
Trial Details
Trial ID
NCT01210430
Start Date
July 1 2010
End Date
June 1 2015
Last Update
June 10 2021
Active Locations (1)
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1
New York Medical College/Bradhurst building
Hawthorne, New York, United States, 10532