Status:
TERMINATED
Connectivity Analysis for Investigation of Auditory Impairment in Epilepsy
Lead Sponsor:
National Institute on Deafness and Other Communication Disorders (NIDCD)
Conditions:
Brain Mapping
Intracranial Central Nervous System Disorder
Eligibility:
All Genders
18-50 years
Brief Summary
Background: * People with epilepsy often have auditory processing disorders that affect their ability to hear clearly and may cause problems with understanding speech and other kinds of verbal commun...
Detailed Description
Objective: Auditory processing disorders are common in patients with epilepsy and adversely impact verbal communication. The neural bases of auditory disorders remain poorly understood, impeding devel...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Normal peripheral hearing: pure tone air conduction thresholds less than or equal to 20 dB HL at octave frequencies between 250-8000 Hz for each ear; word recognition scores in quiet greater than or equal to 88% for each ear; normal 226 Hz tympanometry (middle ear peak pressure at 0 plus/minus 100 daPa and peak compensated static compliance of 0.3-1.5 mmho); no history of chronic otitis media, PE tubes, or hearing loss
- For those participants with epilepsy - seizure onset age \> 10 years
- Normal cognitive function (Full-Scale IQ \>84)
- Absence of any co-morbid neurological disorder
- Absence of highly magnetizable metallic implants, including highly magnetizable dental work
- A negative urine pregnancy test
- For participants with epilepsy scheduled or to-be-scheduled for grid implantation surgery at Johns Hopkins Hospital
- EXCLUSION CRITERIA:
- Evidence of neurological or psychiatric disorder that would interfere with data interpretation, including cognitive impairment
- Presence of a lesion on a previous MRI, except for the following: mesotemporal sclerosis, cortical dysplasia, and dysembryoplastic neuroepithelial tumor.
- Presence of highly magnetizable metallic implants, such as pacemakers, aneurysm clips, cochlear implants and shrapnel fragments, including highly magnetizable dental work, or any significant history of exposure to small metallic objects which may have become lodged in the head or neck.
- For controls (healthy volunteers) only: history of speech-language disorder
Exclusion
Key Trial Info
Start Date :
September 10 2010
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
April 4 2017
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT01212068
Start Date
September 10 2010
End Date
April 4 2017
Last Update
October 6 2017
Active Locations (1)
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1
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892