Status:
COMPLETED
Effect of Oral Rufinamide and Oxcarbazepine on Nerve Excitability, Hyperalgesia, Allodynia and Flare Reaction Compared to Placebo. A Monocenter, Randomized, Double-blind, Cross-over Study
Lead Sponsor:
University of Zurich
Conditions:
Healthy Subjects
Eligibility:
MALE
18-65 years
Brief Summary
Untersuchungen über die Wirkmechanismen von Antiepileptika haben gezeigt, dass durch eine Blockierung von spannungsabhängigen Natrium-Kanälen im Nervensystem die Schmerzübertragung moduliert werden ka...
Eligibility Criteria
Inclusion
- Inclusion criteria: Male
- Age: 18-65 years
- Weight: 50 - 100 kg
- Height: 155 - 195 cm
- Signed and dated informed consent
- Exclusion criteria:
- Contraindications to the class of drugs under study
- Intellectually or mental impaired subjects
- Known hypersensitivity to class of drugs or the investigational product
- Drug abuse
- Known peripheral neuropathies
- Diabetes mellitus
- Chronic alcohol consumption
- Congestive heart disease
- Participants of other studies during study period and 30 days prior to study begin
- Smoker
- Abnormal electrocardiogram
- Any regular concomitant medication
Exclusion
Key Trial Info
Start Date :
October 1 2010
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
January 1 2013
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT01212458
Start Date
October 1 2010
End Date
January 1 2013
Last Update
March 17 2014
Active Locations (1)
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1
University Hospital Zurich, Institut of Anaesthesiology
Zurich, Canton of Zurich, Switzerland, 8091