Status:
COMPLETED
Early Detection of Anthracycline Cardiotoxicity by Echocardiographic Analysis of Myocardial Deformation in 2D Strain
Lead Sponsor:
University Hospital, Bordeaux
Conditions:
Leukemia
Cardiac Toxicity
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
It is now accepted that the anticancer properties of anthracyclines were allowed in many malignancies improve the prognosis of affected populations. However, the cardiotoxicity of anthracyclines is r...
Detailed Description
Analysis of myocardial deformation in its longitudinal component, circumferential and radial, is a new echocardiographic technique for evaluating myocardial function, which has demonstrated its superi...
Eligibility Criteria
Inclusion
- Patient female or male aged between 18 and 65
- Patients with a haematological disease and ran for a first-line chemotherapy including anthracycline
- Patients with a predict cardiovascular score to 10 years below 20% or if higher, with a stress echocardiography using dobutamine, negative, for less than six months.
- Patient or affiliate receiving social security
- Patient informed consent and having oral and written
Exclusion
- A history of chemotherapy or radiotherapy of the left hemithorax
- Significant coronary artery disease: a history of angioplasty, stent, CABG, predict cardiovascular score to 10 years over 20% of stress echocardiography and dobutamine positive (three positive segments)
- Left ventricular hypertrophy (diastolic septum ≥ 10 mm and diastolic posterior wall ≥ 10 mm)
- One or more significant valvulopathy: Rao, RM medium or tight, IM, IT and CAI ≥ grade 2
- Secondary or primary cardiomyopathy (LVEF ≤ 50%)
- Pregnant or lactating
Key Trial Info
Start Date :
September 28 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 25 2015
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT01212926
Start Date
September 28 2010
End Date
May 25 2015
Last Update
February 9 2022
Active Locations (1)
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1
Service de Cardiologie et Maladies Vasculaires, Hopital du Haut Lévêque
Pessac, France, 33604