Status:
COMPLETED
Evaluation of Respiratory Motion-Corrected Cone-Beam CT in Radiation Treatment of Thoracic and Abdominal Cancers
Lead Sponsor:
Memorial Sloan Kettering Cancer Center
Collaborating Sponsors:
University of North Carolina, Chapel Hill
Varian Medical Systems
Conditions:
Gastric Cancer
Lung Cancer
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Tumors must be seen clearly on CT scan to be radiated completely and safely. Breathing causes tumors to move. If the tumor moves during breathing, it can look blurred on the CT scan. This makes it dif...
Eligibility Criteria
Inclusion
- Patients must have histologic proof of a thoracic or abdominal malignancy, confirmed at MSKCC and suitable for radiation therapy, in order to be eligible for this study. Thoracic malignancies (study group 1) include those in lung and gastro-esophageal junction. Abdominal malignancies (study group 2) include those in liver and pancreas. Patients having both thoracic and abdominal malignancies will be placed in only one of the study groups, because the limited field-of-view of the CBCT precludes imaging of both malignancies in the same scan. Patients must be older than 18 years of age
- At least part of the tumor must be visible as observed in a diagnostic or planning CT. The tumor must exhibit at least 5 mm motion from respiration as observed in the respiration-correlated CT (RCCT) at simulation. The RCCT scan must be interpretable and not exhibit excessive motion artifacts caused by irregular patient breathing.
- Patients must have Karnofsky Performance Status ≥ 70%
Exclusion
- Mesothelioma and other tumors of the pleura
- Pregnant Women
- Allergic to iodine or intravenous contrast agent (applies only to patients with a pancreas or liver malignancy)
- Renal impairment due to the use of a contrast agent
- Patients with pacemakers and defibrillators
Key Trial Info
Start Date :
September 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 1 2018
Estimated Enrollment :
52 Patients enrolled
Trial Details
Trial ID
NCT01213004
Start Date
September 1 2010
End Date
February 1 2018
Last Update
February 6 2018
Active Locations (1)
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1
Memorial Sloan Kettering Cancer Center
New York, New York, United States, 10065