Status:
COMPLETED
Cardiac Resynchronisation Study
Lead Sponsor:
Imperial College London
Conditions:
Heart Failure
Eligibility:
All Genders
18+ years
Brief Summary
This study aims to investigate the effect of a pacemaker device used in heart failure patients which is called Cardiac Resynchronisation Therapy (CRT). Specifically the investigators aim to investigat...
Detailed Description
AIM To investigate the effect of Cardiac Resynchronisation Therapy (CRT) on chemosensitivity in patients with Chronic Heart Failure with and without Sleep Disordered Breathing (SDB). OBJECTIVE To con...
Eligibility Criteria
Inclusion
- Age ≥18 years old
- Fulfil the current guidance for the implantation of a CRT device; optimal medical treatment for heart failure, broad QRS complex on electrocardiogram with or without evidence of cardiac dyssynchrony as appropriate, LVEF \<35%, functional impairment as defined by an NYHA class of III-IV
- Clinically stable with no unplanned admission to hospital for preceding 4 weeks
- No changes in medications for heart failure in preceding 4 weeks
- Able to read and understand patient information sheet and give informed consent
Exclusion
- On positive pressure treatment for known sleep disordered breathing at the time of inclusion
- Other known condition (untreated) likely to significantly disturb sleep eg. Restless legs syndrome, pain from any cause etc.
- Pregnancy
Key Trial Info
Start Date :
October 1 2010
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
October 1 2011
Estimated Enrollment :
182 Patients enrolled
Trial Details
Trial ID
NCT01213537
Start Date
October 1 2010
End Date
October 1 2011
Last Update
October 22 2015
Active Locations (1)
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1
Royal Brompton Hospital
London, London, United Kingdom, SW3 6NP