Status:
COMPLETED
The Effects of Atorvastatin on the Nitric Oxide-system in Healthy Young Man
Lead Sponsor:
Regional Hospital Holstebro
Conditions:
Cardiovascular Diseases
Nephropathy
Eligibility:
All Genders
18-40 years
Phase:
PHASE2
Brief Summary
It has been documented that statin reduce mortality and morbidity in patients with cardiovascular disease. This effect can partly be related to a reduction in cholesterol levels in blood. Nitric oxide...
Detailed Description
Subjects will be examined on two examination days. 4 days prior to each examination day subjects are treated with either atorvastatin or placebo. During treatment periods subject are given a standardi...
Eligibility Criteria
Inclusion
- Men and women, age 18-40 years
- Body Mass Index (BMI) 18,5-30 kg/m2
Exclusion
- Arterial hypertension (\>140 mmHg systolic and/or 90 mmHg diastolic)
- Anamnestic or clinical signs of heart, lung, lever, kidney and brain disease
- Neoplastic disease
- Alcohol abuse,
- Drug abuse
- Medical treatment except oral anticontraceptive
- Smoking
- Pregnancy or
- Abnormal blood and urine sample
- Abnormal ECG
- Blood donation within a month before examination
Key Trial Info
Start Date :
May 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2011
Estimated Enrollment :
26 Patients enrolled
Trial Details
Trial ID
NCT01214746
Start Date
May 1 2010
End Date
June 1 2011
Last Update
August 16 2011
Active Locations (1)
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1
Medicinsk Forskning, Regionshospitalet Holstebro
Holstebro, Denmark, 7500