Status:
COMPLETED
Studying Amphetamine Withdrawal in Humans
Lead Sponsor:
University of Arkansas
Conditions:
Methamphetamine Dependence
Eligibility:
All Genders
21-65 years
Phase:
PHASE2
Brief Summary
Methamphetamine use is very common in the US and is associated with serious medical and psychiatric problems. There has also been a significant increase in the number of patients entering treatment fo...
Eligibility Criteria
Inclusion
- 21-65 years old
- not currently enrolled in a treatment program
- history of methamphetamine use with recent use confirmed by a positive urine toxicology screen for amphetamines during the month prior to study entry
- self-reported Methamphetamine use on at least 15 of the past 30 days
- use of at least one half gram of methamphetamine per week during the month prior to study entry
- women of childbearing age must have a negative pregnancy test to enroll in this study
Exclusion
- current diagnosis of alcohol, opiate, or sedative physical dependence
- ill health (e.g., major cardiovascular, renal, endocrine, hepatic disorder)
- history of schizophrenia, or bipolar type I disorder
- present or recent use of over-the-counter or prescription psychoactive drug or drug(s) that would be expected to have major interaction with d-amphetamine
- medical contraindication to receiving study medications (e.g., previous adverse reaction to d-amphetamine)
- chronic pain condition (due to impact on neurophysiological responses
- current suicidality or psychosis
- liver function tests (i.e., liver enzymes) greater than three times normal levels
- pregnancy or breastfeeding
- children 18-20 will be excluded because the P50 potential is not fully developed in children and adolescents
Key Trial Info
Start Date :
October 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2014
Estimated Enrollment :
35 Patients enrolled
Trial Details
Trial ID
NCT01215929
Start Date
October 1 2009
End Date
May 1 2014
Last Update
August 4 2014
Active Locations (1)
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1
University of Arkansas for Medical SCiences
Little Rock, Arkansas, United States, 72205