Status:
COMPLETED
Novel Gentic Variations Contributing to Asthma Susceptability in Saudi Arabia
Lead Sponsor:
King Saud University
Conditions:
Collection of Clinical Data That Will be Used in This Study and Will Form a Data Bank for Asthma in Saudi Arabia
Identify Known and NOVEL Genetic Risk Factors Contributing to Asthma Susceptibility
Eligibility:
All Genders
3+ years
Brief Summary
Research Problem Asthma is one of the most common chronic diseases in the world that affects approximately 300 million individuals worldwide. It is characterized by airway inflammation and bronchocons...
Eligibility Criteria
Inclusion
- Subjects with documented clinical history of asthma for a period of at least 6 months prior to study entry (and a minimum of one clinic follow-up visit since initial diagnosis)
- Willing to provide written informed consent and in the judgment of the investigator, individuals who are able to understand the informed consent process.
- Subjects with documented clinical history (in preceding 12 months) of airway reversibility of at least 12% based on Forced Expiratory Volume (FEV1), measured pre and post inhalation of a β-2 agonist (2 puffs of albuterol using a measured dose inhaler with spacer) OR
- Individuals demonstrating airway 12% reversibility during recruitment testing and asthmatic symptoms, but with no prior history of asthma and not on an asthma treatment plan, can be recruited as affected individuals if in the opinion of the investigator the individuals are truly asthmatic and have no confounding factors that could explain the reversibility and symptoms.
- 7\. Individuals with strong history of asthma but with waning, or no current symptoms may be included in the study if their asthma was well controlled using an asthma medication. Principal investigator must verify or know the clinical history of an individual before accepting him as an asthmatic individual.
- 8\. Individuals with positive history of asthma but no asthma medication usage and with family history of asthma should be considered for inclusion as cases in the study only if other family members are being recruited.
- 9\. Able to perform Spirometry/FEV1 correctly (only for those above 7years).
Exclusion
- Age \< 3 years
- Smoking for 20 years, 1 pack/day or more.
- Congestive heart failure.
- COPD.
- Chronic lung disease other than asthma and COPD.
- Bronchiectasis.
Key Trial Info
Start Date :
October 1 2010
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
September 1 2013
Estimated Enrollment :
2000 Patients enrolled
Trial Details
Trial ID
NCT01216215
Start Date
October 1 2010
End Date
September 1 2013
Last Update
April 15 2014
Active Locations (1)
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1
King Khalid University Hospital, College of Medicne, King saud University
Riyadh, Central, Saudi Arabia, 11461