Status:
COMPLETED
Steroid Titration Against Mannitol IN Asthma
Lead Sponsor:
University of Dundee
Conditions:
Asthma
Eligibility:
All Genders
16-65 years
Phase:
NA
Brief Summary
The investigators hypothesise that titration of asthma medication against mannitol challenge results will reduce the number of mild asthma exacerbations, in one year, when compared with titration agai...
Eligibility Criteria
Inclusion
- Male or female asthmatics aged \>/= 16 years
- Females must be non pregnant and non lactating
- FEV1 \>/= 50% predicted
- Mannitol PD10 \</= 635 mg at end of step down period
- No recent exacerbations of asthma requiring oral prednisolone in the previous 3 months
- Able to perform all the techniques necessary to carry out the challenge testing and lung function and compliant with taking the study medication
- Good inhaler technique which will be reinforced at each study visit
Exclusion
- Male or female patients aged 15 or below
- FEV1 \</= 50% predicted
- Patients who are currently taking a pulse of oral corticosteroids
- Patients with the following concomitant illnesses:bronchiectasis, allergic bronchopulmonary aspergillosis, COPD, heart failure, pulmonary fibrosis, rhino-sinusitis with polyps
- Immunocompromised patients
- Patients with recurrent LRTI
- Patients with documented aspirin induced asthma on LRTAs
- Pregnancy
- Known or suspected hypersensitivity to ICS or other excipients of the MDIs
- HIV/Hepatitis B or C positive
Key Trial Info
Start Date :
March 1 2004
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
Estimated Enrollment :
164 Patients enrolled
Trial Details
Trial ID
NCT01216579
Start Date
March 1 2004
Last Update
October 7 2010
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