Status:
COMPLETED
Clinical Evidence of pH Dependent ß2 Adrenergic Transport Mechanisms in the Airway
Lead Sponsor:
University of Miami
Collaborating Sponsors:
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Conditions:
Healthy Volunteers
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
The purpose of this study was to determine if airway pH has an effect on albuterol-induced vasodilation in the airway. Methods: Ten healthy volunteers performed the following respiratory maneuvers: qu...
Detailed Description
The lungs provide a unique absorptive surface for drug delivery. Many inhaled drugs are rapidly absorbed into the airway because of their lipophilic chemical characteristics. However, the majority of ...
Eligibility Criteria
Inclusion
- Lifetime non-smokers
- FEV1 \> 80% predicted value and FEV1/FVC \> 0.75
Exclusion
- Cardiovascular disease or use of cardiovascular or vasoactive drugs;
- Lung disease or use of airway drugs (i.e. inhaled corticosteroids, β adrenergic agonists);
- Respiratory infection during the 4 weeks preceding the study
- Use of systemic glucocorticoids within 4 weeks of the study
- Pregnant or nursing females
Key Trial Info
Start Date :
January 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2010
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT01216748
Start Date
January 1 2010
End Date
August 1 2010
Last Update
May 27 2016
Active Locations (1)
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1
Pulmonary Human Research Laboratory, University of Miami School of Medicine
Miami, Florida, United States, 33136