Status:
COMPLETED
Japanese Single and Multiple Ascending Dose, Safety, Tolerability, Pharmacokinetic (PK) & Pharmacodynamic (PD) Study of AZD7687
Lead Sponsor:
AstraZeneca
Conditions:
Type 2 Diabetes
Obesity
Eligibility:
MALE
20-45 years
Phase:
PHASE1
Brief Summary
This is a study in Japanese healthy volunteers to determine the safety and tolerability of the compound AZD7687. It will also assess how the body handles the drug and how it responds to the drug follo...
Eligibility Criteria
Inclusion
- Suitable veins for cannulation or repeated venipuncture
- Have a body mass index (BMI) between 19 and 35 kg/m2 and weigh at least 50 kg and no more than 90 kg
- Male subjects should be willing to use barrier contraception ie, condoms with spermicide, from the first day of dosing until 3 months after the last dose of investigational product
Exclusion
- History of any clinically significant disease or disorder which, in the opinion of the Investigator, may either put the subject at risk because of participation in the study, or influence the results or the subject's ability to participate in the study.
- History or presence of gastrointestinal, hepatic or renal disease or any other condition known to interfere with absorption, distribution, metabolism or excretion of drugs
- Any clinically significant illness, medical/surgical procedure or trauma within 4 weeks of the first administration of investigational product
Key Trial Info
Start Date :
November 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 1 2011
Estimated Enrollment :
36 Patients enrolled
Trial Details
Trial ID
NCT01217905
Start Date
November 1 2010
End Date
July 1 2011
Last Update
February 13 2012
Active Locations (1)
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1
Research site
Croydon, United Kingdom