Status:
COMPLETED
Sodium Bicarbonate and N-Acetylcysteine for Nephroprotection in Acute Myocardial Infarction
Lead Sponsor:
Catholic University of the Sacred Heart
Collaborating Sponsors:
Policlinico Casilino ASL RMB
Conditions:
Acute Myocardial Infarction
Acute Kidney Injury
Eligibility:
All Genders
18-89 years
Brief Summary
Contrast-induced nephropathy (CIN) represents a potential complication of diagnostic and therapeutic procedures in interventional cardiology, especially in the acute setting of primary PCI. The invest...
Detailed Description
Introduction Contrast-induced nephropathy (CIN) represents a potential complication of diagnostic and therapeutic procedures in interventional cardiology. In the setting of elective procedures, the st...
Eligibility Criteria
Inclusion
- ST-Segment Elevation Myocardial Infarction (STEMI) as diagnosed according to the ACC (American College of Cardiology) criteria:
- ischemic symptoms;
- ECG variations: ST-elevation (\>0,05 mV) in two or more contiguous leads;
- Increase of the biochemical markers of myocardial necrosis (troponin T, cTNT). • Indication to urgent coronary angiography and primary or rescue PCI
Exclusion
- Patients with history of allergic reaction to NAC
- Chronic hemodialysis
- Age \>= 90 years
Key Trial Info
Start Date :
June 1 2008
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
October 1 2011
Estimated Enrollment :
520 Patients enrolled
Trial Details
Trial ID
NCT01218178
Start Date
June 1 2008
End Date
October 1 2011
Last Update
March 13 2015
Active Locations (1)
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1
Policlinico Agostino Gemelli and Policlinico Casilino
Rome, Italy, 00168