Status:
COMPLETED
Prevention of Contrast Renal Injury With Different Hydration Strategies
Lead Sponsor:
Kaiser Permanente
Conditions:
Contrast Medium-induced Nephropathy
Eligibility:
All Genders
18+ years
Phase:
PHASE3
Brief Summary
Using a randomized controlled trial design, two hydration protocols for the prevention of contrast medium-induced nephropathy will be tested.
Detailed Description
The study population will be recruited from subjects undergoing cardiac catheterization. Subjects will be randomized to one of two hydration protocols: 1. normal saline at 3 mL/kg for one hour prior...
Eligibility Criteria
Inclusion
- estimated GFR less than or equal to 60 mL/min/1.73 m\^2
- age greater than 18 years
- at least one of the following: diabetes mellitus, history of congestive heart failure, hypertension, or age greater than 75 years.
Exclusion
- patients unable to give consent
- undergoing emergency cardiac catheterization
- on renal replacement therapy
- exposure to contrast media within the prior two days
- pulmonary edema or active congestive heart failure
- kidney transplant status
- severe valvular abnormalities
- change in serum creatinine greater than 15% over the prior two days
Key Trial Info
Start Date :
October 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2013
Estimated Enrollment :
396 Patients enrolled
Trial Details
Trial ID
NCT01218828
Start Date
October 1 2010
End Date
January 1 2013
Last Update
March 11 2015
Active Locations (1)
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1
Kaiser Permanente
Los Angeles, California, United States, 90027