Status:
COMPLETED
Study of the Efficacy of 24 Chromosome Preimplantation Genetic Diagnosis (PGD)
Lead Sponsor:
Reproductive Medicine Associates of New Jersey
Conditions:
Effect of PGD on Implantation Rates in IVF Cycles
Eligibility:
FEMALE
21-43 years
Brief Summary
The purpose of this study is to determine if 24 chromosome preimplantation genetic diagnosis (PGD) increases implantation and delivery rates in couples attempting to conceive through in vitro fertiliz...
Detailed Description
FISH based PGD techniques have provided little improvement in implantation and delivery rates. We believe that the use of 24 chromosome PGD, as compared to control (no PGD) will show a benefit to pati...
Eligibility Criteria
Inclusion
- Major
- Age of female partner of \< 43 years
- Normal day-three FSH level (\< 15 mIU/mL)
- Normal uterine cavity
- Sufficient ejaculated spermatozoa in male partner for ART
- Maximum of one prior failed IVF cycle
- Major
Exclusion
- FSH level ≥ 15 mIU/mL
- BMI greater than 32 kg/m2
- Contraindication to gonadotropin stimulation
- Unevaluated Ovarian mass
- Need for surgical sperm removal
- Any contraindication to undergoing in vitro fertilization
- Age greater than 43 years
- Presence of hydrosalpinges which communicate with the endometrial cavity
- Clinical indication for PGD (undergoing IVF with PGD to rule out a known genetic defect)
Key Trial Info
Start Date :
August 1 2009
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
June 1 2013
Estimated Enrollment :
334 Patients enrolled
Trial Details
Trial ID
NCT01219283
Start Date
August 1 2009
End Date
June 1 2013
Last Update
March 26 2015
Active Locations (3)
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1
Colorado Center for Reproductive Medicine
Lone Tree, Colorado, United States, 18104
2
Reproductive Medicine Associates
Morristown, New Jersey, United States, 07960
3
Reproductive Medicine Associates of PA at Lehigh Valley
Allentown, Pennsylvania, United States, 18104