Status:
COMPLETED
A Trial of Standard vs Half Dose Rabeprazole, Clarithromycin, Metronidazole and Amoxicillin in the Treatment of Helicobacter Pylori Infection
Lead Sponsor:
American University of Beirut Medical Center
Conditions:
Helicobacter Infections
Eligibility:
All Genders
18-80 years
Phase:
PHASE4
Brief Summary
The proposed study will test the hypothesis that H. pylori can be eradicated successfully (\>85%) using half-or full-dose "concomitant" non-bismuth quadruple therapy regimen: rabeprazole, amoxicillin,...
Detailed Description
Infection with H. pylori has been linked with chronic active gastritis, peptic ulcer disease, adenocarcinoma and Non-Hodgkin's lymphoma of the stomach. Eradication of this organism has been recommende...
Eligibility Criteria
Inclusion
- documented H.pylori infection by a CLO test or a Urea Breath Test
- sign the informed consent
Exclusion
- Age under 18 or older than 80 years
- Allergies to any of the drugs used
- Recent antibiotic therapy (within 2 weeks of enrolment)
- Severe ulcers or bleeding
- Gastric perforation or obstruction
- Previous gastrectomy
- Gastric cancer
- Pregnancy or lactation
- Prior eradication therapy for H. pylori
- Severe concomitant disease or condition making the treatment unlikely to be effective i.e. alcoholism, drug addiction, and history of poor compliance.
Key Trial Info
Start Date :
October 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2013
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT01219764
Start Date
October 1 2010
End Date
March 1 2013
Last Update
January 27 2014
Active Locations (1)
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1
American University of Beirut - Medical Center
Beirut, Lebanon