Status:
COMPLETED
Pancreatic Intraepithelial Neoplasia (PanIN) and the Association With Recurrence of Pancreatic Adenocarcinoma
Lead Sponsor:
Columbia University
Collaborating Sponsors:
Cold Spring Harbor Laboratory
Conditions:
Pancreatic Cancer
Eligibility:
All Genders
18-85 years
Brief Summary
The research purpose of this project is to create a registry, and blood and tissue bank for individuals at high-risk for pancreatic cancer. We plan to conduct histopathological and molecular analysis ...
Detailed Description
Pancreatic cancer is the fifth leading cause of cancer-related death in the United States. In order to improve outcomes of this disease, significant research efforts have focused on understanding the ...
Eligibility Criteria
Inclusion
- Tissue-confirmed diagnosis of pancreatic adenocarcinoma.
- Underwent surgical resection for adenocarcinoma at Columbia-Presbyterian Medical Center with pathologically negative surgical margins.
- Enrolled in our Pancreatic Cancer Registry and Tissue Bank protocol (AAAA-6154).
- Have at least 2 relatives (of whom one must be first-degree relative) with pancreatic cancer, or have been diagnosed with a a genetic syndrome which is associated with pancreatic cancer (among the included syndromes include BRCA1/2, FAMMM, Peutz-Jeghers, HNPCC, Hereditary Pancreatitis) -OR- Have radiological or pathological (fine needle aspirate or surgical biopsy) evidence of local tumor recurrence following surgery.
Exclusion
- Metastatic disease discovered at presentation or on recurrence (exception is the familial PDC patients)
- Positive surgical margins.
- Lack of clinical followup at one year following surgery
Key Trial Info
Start Date :
March 18 2009
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
April 27 2021
Estimated Enrollment :
5 Patients enrolled
Trial Details
Trial ID
NCT01219829
Start Date
March 18 2009
End Date
April 27 2021
Last Update
June 11 2021
Active Locations (1)
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1
Columbia University Irving Medical Center
New York, New York, United States, 10032