Status:
UNKNOWN
Dexamethasone, Ofatumumab and Bendamustine (DOT) First-line in Mantle-cell Lymphoma(MCL)
Lead Sponsor:
Southern Europe New Drug Organization
Collaborating Sponsors:
Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Conditions:
Lymphoma, Mantle-Cell
Eligibility:
All Genders
60+ years
Phase:
PHASE1
PHASE2
Brief Summary
The rationale for this study design is based on the fact that the maximum tolerated dose (MTD) of single-agent ofatumumab and bendamustine have been previously determined. The choice of the doses for ...
Eligibility Criteria
Inclusion
- Age ≥ 60 years.
- ECOG Performance Status 0-1.
- Life expectancy of at least 6 months.
- Histological diagnosis of MCL (morphology, CD5+/CD20+ /CD23-, t(11:14) and/or cyclin D1 overexpression).
- Disease requiring treatment (patients with bone marrow only disease, who are candidates for a watch-and-wait approach, will be excluded)
- Adequate bone marrow, liver and renal function, unless the abnormality is related to the tumor and is unlikely to affect the safety of bendamustine and ofatumumab use. Adequate marrow and organ function will be assessed by the following laboratory requirements to be conducted within 7 days prior to screening:
- Hemoglobin ≥ 9.0 g/dL
- Absolute neutrophil count (ANC) ≥ 1000/µl
- Platelet count ≥ 75000/µl
- Total bilirubin ≤ 1.5 times the ULN
- AST and ALT ≤ 2.5 x ULN
- Alkaline phosphatase ≤ 4 x ULN
- Serum creatinine ≤ 2.5 x ULN
- PT-INR/PTT \< 1.5 x ULN \[Patients who are being therapeutically anticoagulated with agent such as coumadin or heparin will be allowed to participate provided that no prior evidence of underlying abnormality in these parameters exists\]
- Written informed consent.
Exclusion
- Previous treatment for mantle-cell lymphoma (MCL)
- Chronic or current infectious disease requiring systemic antibiotics, antifungal, or antiviral treatment such as, but not limited to, chronic renal infection, chronic chest infection with bronchiectasis, tuberculosis and active Hepatitis C.
- Other past or current malignancy. Subjects who have been free of malignancy for at least 5 years, or have a history of completely resected non-melanoma skin cancer, or successfully treated in situ carcinoma are eligible.
- Clinically significant cardiac disease including unstable angina, acute myocardial infarction within 6 months prior to Visit 1, congestive heart failure, and arrhythmia requiring therapy, with the exception of extra systoles or minor conduction abnormalities
- History of significant cerebrovascular disease or event with significant symptoms or sequelae
- Glucocorticoid use, unless given in doses ≤ 100 mg/day hydrocortisone (or equivalent dose of other glucocorticoid) for \<7 days for exacerbations other than CLL (e.g., asthma)
- Known HIV positive
- Subjects who have current active hepatic or biliary disease (with exception of patients with Gilbert's syndrome, asymptomatic gallstones, liver metastases or stable chronic liver disease per investigator assessment).
- Positive serology for Hepatitis B (HB) defined as a positive test for HBsAg. In addition, if negative for HBsAg but HBcAb positive and HBsAb negative, a HB DNA test will be performed and if positive the subject will be excluded. Note: If HBcAb positive and HBsAb positive, which is indicative of a past infection, the subject can be included.
- Positive serology for hepatitis C (HC) defined by positive test for HCAb, in which case reflexively perform a HC RIBA immunoblot assay on the same sample to confirm the result.
- Treatment with any known non-marketed drug substance or experimental therapy within 5 terminal half lives or 4 weeks prior to Visit 1, whichever is longer or currently participating in any other interventional clinical study
- Known or suspected inability to comply with study protocol
- History of organ allograft
- Patients with evidence or history of bleeding diathesis.
- Patients undergoing renal dialysis.
- Substance abuse, medical psychological or social conditions that may interfere with the patient's participation in the study or evaluation of the study results.
- Any condition that is unstable or could jeopardize the safety of the patient and their compliance in the study.
Key Trial Info
Start Date :
April 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 1 2012
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT01221103
Start Date
April 1 2010
End Date
June 1 2012
Last Update
September 13 2011
Active Locations (2)
Enter a location and click search to find clinical trials sorted by distance.
1
Fondazione IRCCS Istituto Nazionale Tumori
Milan, Italy, 20133
2
Ospedali Bianchi - Melacrino - Morelli
Reggio Calabria, Italy, 89100